For more detail, see "How this drug works," below. Note: If a drug has been approved for one use, physicians may elect to use this same drug for other problems if they believe it may be helpful. These are less common side effects for patients receiving sorafenib, when compared with those receiving placebo:. A rare but serious effect reported in studies of sorafenib when compared with placebo, was heart problems 2.
Not all side effects are listed above. However, you should always inform your health care provider if you experience any unusual symptoms. Sorafenib may cause unwanted effects on the heart. Contact your health care provider immediately , day or night, if you should experience any of the following symptoms:.
The following symptoms require medical attention, but are not an emergency. Call your doctor if you have any unusual problems while taking this medication. Keep this medication in the container it came in, tightly closed, and out of reach of children. Store it at room temperature and away from excess heat and moisture not in the bathroom. It is important to keep all medication out of sight and reach of children as many containers such as weekly pill minders and those for eye drops, creams, patches, and inhalers are not child-resistant and young children can open them easily.
To protect young children from poisoning, always lock safety caps and immediately place the medication in a safe location — one that is up and away and out of their sight and reach. Unneeded medications should be disposed of in special ways to ensure that pets, children, and other people cannot consume them.
However, you should not flush this medication down the toilet. Instead, the best way to dispose of your medication is through a medicine take-back program. In case of overdose, call the poison control helpline at If the victim has collapsed, had a seizure, has trouble breathing, or can't be awakened, immediately call emergency services at Keep all appointments with your doctor and the laboratory.
Your doctor will order certain lab tests to check your body's response to sorafenib. Your doctor will also check your blood pressure every week during the first six weeks of your treatment and then from time to time as needed.
Do not let anyone else take your medication. Ask your pharmacist any questions you have about refilling your prescription. It is important for you to keep a written list of all of the prescription and nonprescription over-the-counter medicines you are taking, as well as any products such as vitamins, minerals, or other dietary supplements.
You should bring this list with you each time you visit a doctor or if you are admitted to a hospital. It is also important information to carry with you in case of emergencies. Bruix, J. Regorafenib for patients with hepatocellular carcinoma who progressed on sorafenib treatment RESORCE : a randomised, double-blind, placebo-controlled, phase 3 trial. Lancet , 56—66 Zhu, A. Ramucirumab versus placebo as second-line treatment in patients with advanced hepatocellular carcinoma following first-line therapy with sorafenib REACH : a randomised, double-blind, multicentre, phase 3 trial.
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Ye, J. Onco Targets Ther. Sui, C. Cell Mol. Wang, Z. Anti-GPC3 antibody tagged cationic switchable lipid-based nanoparticles for the co-delivery of anti-miRNA27a and sorafenib in liver cancers. Zhang, M et al. MiRb re-sensitizes hepatocellular carcinoma cells to sorafenib therapy by antagonizing PKM2-mediated glycolysis pathway. Jiang, X. Callegari, E. Nucleic Acids 11 , — Pollutri, D. The epigenetically regulated miR associates with stem-cell phenotype and induces sorafenib resistance in hepatocellular carcinoma.
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This drug can slow wound healing. If you need to have an operation you may need to stop taking it for a while beforehand. Your doctor will let you know when you can start taking it again. The length of time depends on the treatment you are having. Ask your doctor or pharmacist how long you should avoid live vaccinations. Contact with others who have had immunisations - You can be in contact with other people who have had live vaccines as injections.
Avoid close contact with people who have recently had live vaccines taken by mouth oral vaccines such as the oral typhoid vaccine. If your immune system is severely weakened, you should avoid contact with children who have had the flu vaccine as a nasal spray. This is for 2 weeks following their vaccination.
Babies have the live rotavirus vaccine. Get someone else to change their nappies during this time if you can. If this isn't possible, wash your hands well after changing their nappy. Your guide to primary liver cancer, including information about getting diagnosed, the different types and stages of liver cancer, and treatments for the most common type of liver cancer hepatocellular carcinoma.
If you have cancer that started in another part of your body and has spread to your liver you need to go to our information about secondary liver cancer. The thyroid is a small butterfly shaped gland that makes and releases hormones. Thyroid cancer is when abnormal cells in the thyroid gland start to divide and grow in an uncontrolled way. Kidney cancer is called advanced if it has spread to another part of the body. See how it may affect your life and what treatments and support are available.
Cancer drugs have side effects and these can vary from person to person. But there are things that you can do to help you cope. Coping with cancer can be difficult. There is help and support available.
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Sorafenib is a cancer treatment and is also known by its brand name, Nexavar.
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